Direct synthesis of methyl phosphoramidates in carbohydrates.
نویسندگان
چکیده
A direct installation of a methyl phosphoramidate group by using methyl benzylphosphoramidochloridate into carbohydrates and amino acid is described. This one-step synthesis is efficient for both primary and secondary alcohols and exhibited excellent regioselectivity and functional group compatibility. Formation of a single diastereomer is observed in certain cases. The N-benzyl protecting group on methyl phosphoramidates is easily removed under mild conditions.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 36 شماره
صفحات -
تاریخ انتشار 2015